Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors

Tony K.M. Shing, Wai Lung Ng, Judy Y.W. Chan, Clara B.S. Lau

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.

本文言語English
ページ(範囲)8401-8405
ページ数5
ジャーナルAngewandte Chemie - International Edition
52
32
DOI
出版ステータスPublished - 2013 8月 5

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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