抄録
Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.
本文言語 | English |
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ページ(範囲) | 8401-8405 |
ページ数 | 5 |
ジャーナル | Angewandte Chemie - International Edition |
巻 | 52 |
号 | 32 |
DOI | |
出版ステータス | Published - 2013 8月 5 |
ASJC Scopus subject areas
- 触媒
- 化学 (全般)