Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes

Kenichiro Shimokawa, Kaoru Yamada, Osamu Ohno, Yuichi Oba, Daisuke Uemura

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The design, synthesis, and biological activity of biotin-labeled (-)-ternatin are reported. Chemical modification, that is, biotinylation, was conducted using Click chemistry at the 6-position (NMe-d-ProGly moiety), which was a plausible location selected on the basis of our SAR studies. The compound displayed sufficient fat-accumulation inhibitory effect against 3T3-L1 adipocytes for further bio-organic studies.

本文言語English
ページ(範囲)92-95
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
19
1
DOI
出版ステータスPublished - 2009 1 1

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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