Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates

Kazunobu Toshima; Kazumi Ohta; Aya Ohashi; Takatsugu Nakamura; Masaya Nakata; Shuichi Matsumura

doi:10.1039/C39930001525

Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates

Kazunobu Toshima, Kazumi Ohta, Aya Ohashi, Takatsugu Nakamura, Masaya Nakata, Shuichi Matsumura

応用化学科

研究成果: Article › 査読

23 被引用数 (Scopus)

抄録

The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.

本文言語	English
ページ（範囲）	1525-1527
ページ数	3
ジャーナル	Journal of the Chemical Society, Chemical Communications
号	19
DOI	https://doi.org/10.1039/C39930001525
出版ステータス	Published - 1993 12月 1

ASJC Scopus subject areas

分子医療

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10.1039/C39930001525

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「Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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