[Destruction of the articular cartilage in osteoarthritis].

Masashi Okubo, Yasunori Okada

研究成果: Review article査読

16 被引用数 (Scopus)

抄録

Osteoarthritis (OA) is the most common joint disease characterized by destruction of articular cartilage induced primarily by mechanical stresses to joints. Destruction of the articular cartilage in OA is caused by combination of increased degradation of ECM (extracellular matrix) , decreased production of ECM and chondrocyte death. Members of the MMP (matrix metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene families are considered to play a key role in the degradation of cartilage.

本文言語English
ページ(範囲)1705-1713
ページ数9
ジャーナルClinical calcium
23
12
出版ステータスPublished - 2013 12

ASJC Scopus subject areas

  • 医学(全般)

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