抄録
A method for increasing the specificity of detecting a DNA point mutation and the sensitivity of evanescent wave based biosensors was presented. A peptide nucleic acid (PNA) ligand was used to increase the specificity to detect G-G mismatch in K-ras gene affiliated with pancreatic cancer. It was observed that affinity constants between complementary and mismatched targets was of the order of 102 and the largest for PNA interacting with 11mer targets. The results show that change in flow rate has a different effect on the stability of microspheres in a sandwitched geometry that are hybridized to the surface.
| 本文言語 | English |
|---|---|
| ホスト出版物のタイトル | Transactions - 7th World Biomaterials Congress |
| ページ数 | 1 |
| 出版ステータス | Published - 2004 12月 1 |
| イベント | Transactions - 7th World Biomaterials Congress - Sydney, Australia 継続期間: 2004 5月 17 → 2004 5月 21 |
出版物シリーズ
| 名前 | Transactions - 7th World Biomaterials Congress |
|---|
Other
| Other | Transactions - 7th World Biomaterials Congress |
|---|---|
| 国/地域 | Australia |
| City | Sydney |
| Period | 04/5/17 → 04/5/21 |
ASJC Scopus subject areas
- 工学（全般）
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
