Detection of C-type natriuretic peptide in human circulation and marked increase of plasma CNP level in septic shock patients

Norio Hama, Hiroshi Itoh, Gotaro Shirakami, Shin Ichi Suga, Yasato Komatsu, Takaaki Yoshimasa, Issei Tanaka, Kenjiro Mori, Kazuwa Nakao

研究成果: Article

125 引用 (Scopus)


We have previously reported that C-type natriuretic peptide (CNP), the third member of natriuretic family, was produced in vascular endothelial cells and hypothesized that CNP might be a local regulator of vascular tone and/or growth from endothelial cells. In order to clarify the pathophysiological significance of CNP in humans, we examined the presence of CNP in human circulation and determined plasma levels of CNP in patients with various cardiovascular disorders. The plasma level of CNP in healthy persons was 1.4 ± 0.6 fmol/ml (n=13). The plasma level of CNP was markedly increased in patients with septic shock (13.2 ± 10.1 fmol/ml, n=11), while there was no alteration in patients with congestive heart failure or hypertension. There was two-fold increase of the plasma CNP level in patients with chronic renal failure. These results indicate that CNP, which can be considered as an endothelium-derived relaxing peptide, is detectable in human circulation and suggest the pathophysiological significance of endothelial CNP in humans.

ジャーナルBiochemical and Biophysical Research Communications
出版物ステータスPublished - 1994 2 14


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology