Detection of Multidrug Resistance Markers, P-Glycoprotein and mdrl mRNA, in Human Leukemia Cells

Takashi Tsuruo, Yoshikazu Sugimoto, Hirofumi Hamada, Igor Roninson, Masao Okumura, Koichi Adachi, Yasuo Morishima, Ryuzo Ohno

研究成果: Article査読

74 被引用数 (Scopus)

抄録

We have examined the expression of P-glycoprotein in clinical leukemic cell samples by using a monoclonal antibody (MRK16) against P-glycoprotein. We found that leukemia cells isolated from 3 out of 6 patients with blast crisis of chronic myelogenous leukemia were reactive to MRK16. These 3 cell lines expressed high levels of mdrl mRNA, which codes for P-glycoprotein. The present result indicates that the clinically refractory state of the tumor may be predicted in part by determining P-glycoprotein expression using the monoclonal antibody against P-glycoprotein, and the mdrl probe.

本文言語English
ページ(範囲)1415-1419
ページ数5
ジャーナルJapanese Journal of Cancer Research GANN
78
12
出版ステータスPublished - 1987
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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