Determination of absolute stereochemistry, total synthesis, and evaluation of peptides from the myxomycete Physarum melleum

Shuwa Hanazawa, Midori A. Arai, Xiaofan Li, Masami Ishibashi

研究成果: Article査読

14 被引用数 (Scopus)

抄録

The absolute stereochemistry of melleumin A (1) and B (2), novel peptide compounds isolated from the myxomycete Physarum melleum, was determined by synthesis of their segments and by a modified Mosher's method. Total synthesis of melleumin B (2) was achieved by a stereoselective method, which provided further evidence for all the absolute stereochemistries of melleumin B (2). The Wnt signal inhibitory activities of 2 and its 10R-epimer 19 were evaluated. Compound 19 showed moderate inhibition of Wnt signal transcription, which suggests that melleumin analogues might be useful as Wnt signal inhibitors.

本文言語English
ページ(範囲)95-98
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
18
1
DOI
出版ステータスPublished - 2008 1 1
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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