Development and biological evaluation of apatite fibre scaffolds with large pore size and high porosity for bone regeneration

Mamoru Aizawa, Hiroki Shinoda, Hiroshi Uchida, Kiyoshi Itatani, Isao Okada, Morio Matsumoto, Hikaru Morisue, Hideo Matsumoto, Yoshiaki Toyama

研究成果: Conference article

12 引用 (Scopus)

抜粋

Novel scaffolds have been developed from single-crystal apatite fibres synthesized by a homogeneous precipitation method using urea. The resulting apatite fibre scaffolds have large pores with diameters of 110-250 μm and high porosities of 98-99%. The scaffolds were biologically evaluated using two kinds of cells, osteoblast cells (MC3T3-E1) and rat bone marrow cells. In both cases, the cells cultured in the scaffolds showed excellent cellular response, such as good cell proliferation and enhanced differentiation into osteoblasts. We conclude that such scaffolds with high porosity and large pore size may be effective as the matrix of tissue engineered structures in order to promote regeneration of bone.

元の言語English
ページ(範囲)647-650
ページ数4
ジャーナルKey Engineering Materials
240-242
出版物ステータスPublished - 2003 1 1
イベントProceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine - Sydney, NSW, Australia
継続期間: 2002 12 42002 12 8

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • これを引用

    Aizawa, M., Shinoda, H., Uchida, H., Itatani, K., Okada, I., Matsumoto, M., Morisue, H., Matsumoto, H., & Toyama, Y. (2003). Development and biological evaluation of apatite fibre scaffolds with large pore size and high porosity for bone regeneration. Key Engineering Materials, 240-242, 647-650.