Development and maintenance of intestinal regulatory T cells

研究成果: Review article査読

257 被引用数 (Scopus)

抄録

Gut-resident forkhead box P3 (FOXP3) + CD4 + regulatory T cells (T reg cells) are distinct from those in other organs and have gut-specific phenotypes and functions. Whereas T reg cells in other organs have T cell receptors (TCRs) specific for self antigens, intestinal T reg cells have a distinct set of TCRs that are specific for intestinal antigens, and these cells have pivotal roles in the suppression of immune responses against harmless dietary antigens and commensal microorganisms. The differentiation, migration and maintenance of intestinal T reg cells are controlled by specific signals from the local environment. In particular, certain members of the microbiota continuously provide antigens and immunoregulatory small molecules that modulate intestinal T reg cells. Understanding the development and the maintenance of intestinal T reg cells provides important insights into disease-relevant host-microorganism interactions.

本文言語English
ページ(範囲)295-309
ページ数15
ジャーナルNature Reviews Immunology
16
5
DOI
出版ステータスPublished - 2016 4 28

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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