Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina

研究成果: Conference contribution

8 被引用数 (Scopus)

抄録

Retina is a highly vascularized tissue with a high oxygen and metabolic demand receiving light located in the back of the eye. The development and the maintenance of the retinal vasculature are important to regulate the homeostasis in the tissue. α Subunits of hypoxia-inducible factor (HIF) are key molecules in hypoxia response inducing genes required for cell survival such as vascular endothelial growth factor under hypoxia. Neurons, glia, and vascular endothelium cells interdependently form neurovascular unit in the retina tightly regulated by hypoxia response via HIF expression. A corruption of the precise hypoxia response in the developmental or matured retinal tissue may lead congenital vascular anomalies or adult neovascular ocular diseases. To regulate hypoxia response through HIF activity would be an ideal therapeutic target for these vision-threatening eye diseases.

本文言語English
ホスト出版物のタイトルNew Horizons in Neurovascular Coupling
ホスト出版物のサブタイトルA Bridge Between Brain Circulation and Neural Plasticity, 2016
編集者Kazuto Masamoto, Hajime Hirase, Katsuya Yamada
出版社Elsevier B.V.
ページ201-211
ページ数11
ISBN(印刷版)9780444637048
DOI
出版ステータスPublished - 2016

出版物シリーズ

名前Progress in Brain Research
225
ISSN(印刷版)0079-6123
ISSN(電子版)1875-7855

ASJC Scopus subject areas

  • 神経科学(全般)

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