Development of a highly selective fluorescence probe for hydrogen sulfide

Kiyoshi Sasakura; Kenjiro Hanaoka; Norihiro Shibuya; Yoshinori Mikami; Yuka Kimura; Toru Komatsu; Tasuku Ueno; Takuya Terai; Hideo Kimura; Tetsuo Nagano

doi:10.1021/ja207851s

Development of a highly selective fluorescence probe for hydrogen sulfide

Kiyoshi Sasakura, Kenjiro Hanaoka, Norihiro Shibuya, Yoshinori Mikami, Yuka Kimura, Toru Komatsu, Tasuku Ueno, Takuya Terai, Hideo Kimura, Tetsuo Nagano

研究成果: Article › 査読

568 被引用数 (Scopus)

抄録

Hydrogen sulfide (H ₂S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H ₂S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry to control the fluorescence. HSip-1 showed high selectivity and high sensitivity for H ₂S, and its potential for biological applications was confirmed by employing it for fluorescence imaging of H ₂S in live cells.

本文言語	English
ページ（範囲）	18003-18005
ページ数	3
ジャーナル	Journal of the American Chemical Society
巻	133
号	45
DOI	https://doi.org/10.1021/ja207851s
出版ステータス	Published - 2011 11月 16
外部発表	はい

ASJC Scopus subject areas

触媒
化学 (全般)
生化学
コロイド化学および表面化学

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AU - Sasakura, Kiyoshi

AU - Hanaoka, Kenjiro

AU - Shibuya, Norihiro

AU - Mikami, Yoshinori

AU - Kimura, Yuka

AU - Komatsu, Toru

AU - Ueno, Tasuku

AU - Terai, Takuya

AU - Kimura, Hideo

AU - Nagano, Tetsuo

PY - 2011/11/16

Y1 - 2011/11/16

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AB - Hydrogen sulfide (H 2S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H 2S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry to control the fluorescence. HSip-1 showed high selectivity and high sensitivity for H 2S, and its potential for biological applications was confirmed by employing it for fluorescence imaging of H 2S in live cells.

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Development of a highly selective fluorescence probe for hydrogen sulfide

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