Development of a photocurable gelatin-based gelation material for application to periodontal regeneration

Chie Fukaya, Ayaka Ishikawa, Yasuhide Nakayama, Yoshinobu Murayama, Sadao Omata, Yasuo Hosaka, Taneaki Nakagawa

研究成果: Article査読

2 被引用数 (Scopus)


Novel photocurable materials, comprised mixed aqueous solutions of photoreactive gelatin - gelatin partially derivatized with eosin - and polyamine, which is a polymer of N,N-dimethylaminopropylacrylamide, were designed. The materials had appropriate viscosity for shape formation at 37 °C.When photoirradiated with a clinically used visible light source, the materials were almost completely converted to hydrogels to fix their shape in the desired form within several tenths of a second. Cells that were seeded on the eosin-gelatin-coated surface showed good proliferation. Negligible cytotoxicity of eosin-gelatinwas confirmed when culturing was performed in the presence of a large amount of eosin-gelatin. The developed photocurable materials could be converted to a hydrogel with desired physical property change by using a convenient curing procedure of photoirradiation at any desired time and in any shape with minimal cytotoxicity, which was appropriate for the application in periodontal tissue regeneration.

ジャーナルJournal of Photochemistry and Photobiology A: Chemistry
出版ステータスPublished - 2008 9 25

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)

フィンガープリント 「Development of a photocurable gelatin-based gelation material for application to periodontal regeneration」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。