Development of a small-molecule-based activatable photoacoustic probe

Takayuki Ikeno, Kenjiro Hanaoka, Yasuteru Urano

研究成果: Chapter

抄録

Photoacoustic (PA) imaging is an emerging imaging modality that combines the advantages of optical imaging and ultrasound imaging. In particular, activatable PA probes, which visualize the presence or the activity of target molecules in terms of a change of the PA signal, are useful tools for functional imaging. In this chapter, we describe the development of small-molecule-based activatable PA probes, focusing on the design and synthesis of PA-MMSiNQ, our recently developed activatable PA probe for HOCl. We also describe the protocols used for evaluation of PA-MMSiNQ with a UV–vis spectrometer and a PA imaging microscope.

本文言語English
ホスト出版物のタイトルPhotoacoustic Probes for In Vivo Imaging
編集者Jefferson Chan
出版社Academic Press Inc.
ページ1-19
ページ数19
ISBN(印刷版)9780323855303
DOI
出版ステータスPublished - 2021 1
外部発表はい

出版物シリーズ

名前Methods in Enzymology
657
ISSN(印刷版)0076-6879
ISSN(電子版)1557-7988

ASJC Scopus subject areas

  • 生化学
  • 分子生物学

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