@inbook{de88eb4c0cc247feb321efaa8895f37a,
title = "Development of a small-molecule-based activatable photoacoustic probe",
abstract = "Photoacoustic (PA) imaging is an emerging imaging modality that combines the advantages of optical imaging and ultrasound imaging. In particular, activatable PA probes, which visualize the presence or the activity of target molecules in terms of a change of the PA signal, are useful tools for functional imaging. In this chapter, we describe the development of small-molecule-based activatable PA probes, focusing on the design and synthesis of PA-MMSiNQ, our recently developed activatable PA probe for HOCl. We also describe the protocols used for evaluation of PA-MMSiNQ with a UV–vis spectrometer and a PA imaging microscope.",
keywords = "Activatable PA probes, Bioimaging, Chemical probes, Dark quenchers, Near-infrared dyes, Photoacoustic imaging, Si-rhodamines",
author = "Takayuki Ikeno and Kenjiro Hanaoka and Yasuteru Urano",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = jan,
doi = "10.1016/bs.mie.2021.06.041",
language = "English",
isbn = "9780323855303",
series = "Methods in Enzymology",
publisher = "Academic Press Inc.",
pages = "1--19",
editor = "Jefferson Chan",
booktitle = "Photoacoustic Probes for In Vivo Imaging",
address = "United States",
}