Development of consensus statements for the diagnosis and management of intestinal Behçet's disease using a modified Delphi approach

Kenji Kobayashi, Fumiaki Ueno, Seiji Bito, Yasushi Iwao, Tsuneo Fukushima, Nobuo Hiwatashi, Masahiro Igarashi, Bun Ei Iizuka, Takahide Matsuda, Toshiyuki Matsui, Takayuki Matsumoto, Akira Sugita, Mitsuhiro Takeno, Toshifumi Hibi

研究成果: Article

85 引用 (Scopus)

抄録

Background: Although intestinal Behçet's disease has been treated anecdotally with various therapeutic modalities, clinical evidence regarding management of intestinal Behçet's disease is lacking. The objective of this study was to develop consensus-based practice guidelines for diagnosis and treatment of intestinal Behçet's disease by using a modified Delphi approach. Methods: Three groups of Japanese gastroenterology specialists were involved in the study: moderators, an expert panel, and a professional group. Clinical statements for ratings were extracted from relevant literature, a survey of the professional group, and by discussion among the expert panel. The expert panel rated the clinical statements according to a nine point scale. After the first round of ratings, a panelist meeting was held to discuss areas of disagreement and to clarify areas of uncertainty. The list of clinical statements was revised after the panelist meeting, and a second round of rating was conducted. Results: Thirty-two relevant articles were selected in a literature search, and 35 clinical statements were extracted. An additional 209 clinical statements were developed from the survey and discussion among gastroenterology specialists. In the first and second rounds, 56% and 60% of statements, respectively, received median scores ≥7. The range of scores decreased considerably from the first to the second round. Conclusions: 5-Aminosalycylic acid, corticosteroids, immunosuppressants, enteral nutrition, total parenteral nutrition, and surgical therapy were considered standard therapy for intestinal Behçet's disease. Infliximab, colchicines, thalidomide, other pharmacological therapy, endoscopic therapy, and leukocytapheresis were deemed experimental therapy. Based on a two-round modified Delphi approach, practice guidelines for diagnosis and treatment of intestinal Behçet's disease were developed.

元の言語English
ページ(範囲)737-745
ページ数9
ジャーナルJournal of Gastroenterology
42
発行部数9
DOI
出版物ステータスPublished - 2007 9

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Intestinal Diseases
Consensus
Gastroenterology
Practice Guidelines
Therapeutics
Nutrition Therapy
Leukapheresis
Investigational Therapies
Thalidomide
Total Parenteral Nutrition
Colchicine
Enteral Nutrition
Immunosuppressive Agents
Uncertainty
Adrenal Cortex Hormones
Pharmacology
Acids

ASJC Scopus subject areas

  • Gastroenterology

これを引用

Development of consensus statements for the diagnosis and management of intestinal Behçet's disease using a modified Delphi approach. / Kobayashi, Kenji; Ueno, Fumiaki; Bito, Seiji; Iwao, Yasushi; Fukushima, Tsuneo; Hiwatashi, Nobuo; Igarashi, Masahiro; Iizuka, Bun Ei; Matsuda, Takahide; Matsui, Toshiyuki; Matsumoto, Takayuki; Sugita, Akira; Takeno, Mitsuhiro; Hibi, Toshifumi.

:: Journal of Gastroenterology, 巻 42, 番号 9, 09.2007, p. 737-745.

研究成果: Article

Kobayashi, K, Ueno, F, Bito, S, Iwao, Y, Fukushima, T, Hiwatashi, N, Igarashi, M, Iizuka, BE, Matsuda, T, Matsui, T, Matsumoto, T, Sugita, A, Takeno, M & Hibi, T 2007, 'Development of consensus statements for the diagnosis and management of intestinal Behçet's disease using a modified Delphi approach', Journal of Gastroenterology, 巻. 42, 番号 9, pp. 737-745. https://doi.org/10.1007/s00535-007-2090-4
Kobayashi, Kenji ; Ueno, Fumiaki ; Bito, Seiji ; Iwao, Yasushi ; Fukushima, Tsuneo ; Hiwatashi, Nobuo ; Igarashi, Masahiro ; Iizuka, Bun Ei ; Matsuda, Takahide ; Matsui, Toshiyuki ; Matsumoto, Takayuki ; Sugita, Akira ; Takeno, Mitsuhiro ; Hibi, Toshifumi. / Development of consensus statements for the diagnosis and management of intestinal Behçet's disease using a modified Delphi approach. :: Journal of Gastroenterology. 2007 ; 巻 42, 番号 9. pp. 737-745.
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abstract = "Background: Although intestinal Beh{\cc}et's disease has been treated anecdotally with various therapeutic modalities, clinical evidence regarding management of intestinal Beh{\cc}et's disease is lacking. The objective of this study was to develop consensus-based practice guidelines for diagnosis and treatment of intestinal Beh{\cc}et's disease by using a modified Delphi approach. Methods: Three groups of Japanese gastroenterology specialists were involved in the study: moderators, an expert panel, and a professional group. Clinical statements for ratings were extracted from relevant literature, a survey of the professional group, and by discussion among the expert panel. The expert panel rated the clinical statements according to a nine point scale. After the first round of ratings, a panelist meeting was held to discuss areas of disagreement and to clarify areas of uncertainty. The list of clinical statements was revised after the panelist meeting, and a second round of rating was conducted. Results: Thirty-two relevant articles were selected in a literature search, and 35 clinical statements were extracted. An additional 209 clinical statements were developed from the survey and discussion among gastroenterology specialists. In the first and second rounds, 56{\%} and 60{\%} of statements, respectively, received median scores ≥7. The range of scores decreased considerably from the first to the second round. Conclusions: 5-Aminosalycylic acid, corticosteroids, immunosuppressants, enteral nutrition, total parenteral nutrition, and surgical therapy were considered standard therapy for intestinal Beh{\cc}et's disease. Infliximab, colchicines, thalidomide, other pharmacological therapy, endoscopic therapy, and leukocytapheresis were deemed experimental therapy. Based on a two-round modified Delphi approach, practice guidelines for diagnosis and treatment of intestinal Beh{\cc}et's disease were developed.",
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AU - Kobayashi, Kenji

AU - Ueno, Fumiaki

AU - Bito, Seiji

AU - Iwao, Yasushi

AU - Fukushima, Tsuneo

AU - Hiwatashi, Nobuo

AU - Igarashi, Masahiro

AU - Iizuka, Bun Ei

AU - Matsuda, Takahide

AU - Matsui, Toshiyuki

AU - Matsumoto, Takayuki

AU - Sugita, Akira

AU - Takeno, Mitsuhiro

AU - Hibi, Toshifumi

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Y1 - 2007/9

N2 - Background: Although intestinal Behçet's disease has been treated anecdotally with various therapeutic modalities, clinical evidence regarding management of intestinal Behçet's disease is lacking. The objective of this study was to develop consensus-based practice guidelines for diagnosis and treatment of intestinal Behçet's disease by using a modified Delphi approach. Methods: Three groups of Japanese gastroenterology specialists were involved in the study: moderators, an expert panel, and a professional group. Clinical statements for ratings were extracted from relevant literature, a survey of the professional group, and by discussion among the expert panel. The expert panel rated the clinical statements according to a nine point scale. After the first round of ratings, a panelist meeting was held to discuss areas of disagreement and to clarify areas of uncertainty. The list of clinical statements was revised after the panelist meeting, and a second round of rating was conducted. Results: Thirty-two relevant articles were selected in a literature search, and 35 clinical statements were extracted. An additional 209 clinical statements were developed from the survey and discussion among gastroenterology specialists. In the first and second rounds, 56% and 60% of statements, respectively, received median scores ≥7. The range of scores decreased considerably from the first to the second round. Conclusions: 5-Aminosalycylic acid, corticosteroids, immunosuppressants, enteral nutrition, total parenteral nutrition, and surgical therapy were considered standard therapy for intestinal Behçet's disease. Infliximab, colchicines, thalidomide, other pharmacological therapy, endoscopic therapy, and leukocytapheresis were deemed experimental therapy. Based on a two-round modified Delphi approach, practice guidelines for diagnosis and treatment of intestinal Behçet's disease were developed.

AB - Background: Although intestinal Behçet's disease has been treated anecdotally with various therapeutic modalities, clinical evidence regarding management of intestinal Behçet's disease is lacking. The objective of this study was to develop consensus-based practice guidelines for diagnosis and treatment of intestinal Behçet's disease by using a modified Delphi approach. Methods: Three groups of Japanese gastroenterology specialists were involved in the study: moderators, an expert panel, and a professional group. Clinical statements for ratings were extracted from relevant literature, a survey of the professional group, and by discussion among the expert panel. The expert panel rated the clinical statements according to a nine point scale. After the first round of ratings, a panelist meeting was held to discuss areas of disagreement and to clarify areas of uncertainty. The list of clinical statements was revised after the panelist meeting, and a second round of rating was conducted. Results: Thirty-two relevant articles were selected in a literature search, and 35 clinical statements were extracted. An additional 209 clinical statements were developed from the survey and discussion among gastroenterology specialists. In the first and second rounds, 56% and 60% of statements, respectively, received median scores ≥7. The range of scores decreased considerably from the first to the second round. Conclusions: 5-Aminosalycylic acid, corticosteroids, immunosuppressants, enteral nutrition, total parenteral nutrition, and surgical therapy were considered standard therapy for intestinal Behçet's disease. Infliximab, colchicines, thalidomide, other pharmacological therapy, endoscopic therapy, and leukocytapheresis were deemed experimental therapy. Based on a two-round modified Delphi approach, practice guidelines for diagnosis and treatment of intestinal Behçet's disease were developed.

KW - Consensus statements

KW - Delphi approach

KW - Intestinal Behçet's disease

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