Development of mesenchymal stem cells partially originate from the neural crest

Satoru Morikawa, Yo Mabuchi, Kunimichi Niibe, Sadafumi Suzuki, Narihito Nagoshi, Takehiko Sunabori, Shigeto Shimmura, Yasuo Nagai, Taneaki Nakagawa, Hideyuki Okano, Yumi Matsuzaki

研究成果: Article査読

195 被引用数 (Scopus)


Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells isolated from many adult tissues. Previous studies reported that MSCs can differentiate to both mesodermal and neural lineages by a phenomenon referred to as ''dedifferentiation'' or ''transdifferentiation''. However, since MSCs have only been defined in vitro, much of their development in vivo is still unknown. Here, we prospectively identified MSCs in the bone marrow from adult transgenic mice encoding neural crest-specific P0-Cre/Floxed-EGFP and Wnt1-Cre/Floxed-EGFP. EGFP-positive MSCs formed spheres that expressed neural crest stem cell genes and differentiated into neurons, glial cells, and myofibroblasts. Interestingly, we observed MSCs both in the GFP+ and GFP- fraction and found that there were no significant differences in the in vitro characteristics between these two populations. Our results suggest that MSCs in adult bone marrow have at least two developmental origins, one of which is the neural crest.

ジャーナルBiochemical and Biophysical Research Communications
出版ステータスPublished - 2009 2月 20

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学


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