Development of nanocarriers functionalized with stimuli-responsive polymer for controlled cellular uptake

Tsubasa Yamanouchi, Naoya Katsuyama, Yuki Hiruta, Eri Ayano, Hideko Kanazawa

研究成果: Article

1 引用 (Scopus)

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Drug delivery system (DDS) is a technology that controls sustained release of medicines in the body and localized delivery to diseased tissues. Therefore, it is possible to keep the concentration of medicine at therapeutically effective concentrations for a long time and to reduce side effects. We have achieved controlled intracellular uptake, and release of medicines by nanocarriers modified with stimuli-responsive polymers based on poly(N-isopropylacrylamide), which undergoes a reversible phase transition in response to external temperature stimulation. In this article, we introduce our recent research on the design of temperature- and pH-responsive polymers, which enables selective intracellular uptake with external stimulation, and applications to DDS of an anti-tumor agent and siRNA by micelle and liposomes modified with those polymers.

元の言語English
ページ(範囲)116-127
ページ数12
ジャーナルKobunshi Ronbunshu
75
発行部数2
DOI
出版物ステータスPublished - 2018 3 1

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics

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