@article{299ece21ff4e4044a5567cedd5e0ebb9,
title = "Development of necrotizing myopathy following interstitial lung disease with anti-signal recognition particle antibody",
abstract = "A 72-year-old man was admitted due to dyspnea on exertion with interstitial shadows and elevated serum creatinine kinase (CK). Despite a close examination, which included magnetic resonance imaging (MRI), we could not diagnose myopathy. Prednisolone was administered and gradually tapered. One year later, anti-signal recognition particle (SRP) antibody was confirmed and he was re-admitted for hypoxemia with elevated CK. MRI revealed muscle edema and a histopathological examination of a muscle biopsy specimen showed necrotizing myopathy. Prednisolone, cyclosporine, and intravenous immunoglobulin were administered. Physicians should carefully monitor muscle symptoms and serum CK levels in cases of interstitial lung disease with anti-SRP antibodies.",
keywords = "Anti-SRP antibody, Anti-signal recognition particle antibody, ILD, Interstitial lung disease, Necrotizing myopathy",
author = "Tatsuya Kusumoto and Satoshi Okamori and Keita Masuzawa and Takanori Asakura and Naoshi Nishina and Shotaro Chubachi and Katsuhiko Naoki and Koichi Fukunaga and Tomoko Betsuyaku",
note = "Funding Information: We are grateful to Dr. Matsubara of the Tokyo Metropolitan Neurological Hospital for providing assistance in making the pathological diagnosis, and Professor Kuwana of the Nippon Medical School Graduate School of Medicine for the detection of autoantibodies. Publisher Copyright: {\textcopyright} 2018 The Japanese Society of Internal Medicine.",
year = "2018",
doi = "10.2169/internalmedicine.0303-17",
language = "English",
volume = "57",
pages = "2045--2049",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "14",
}