Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light

Satoshi Iwano, Rika Obata, Chihiro Miura, Masahiro Kiyama, Kazutoshi Hama, Mitsuhiro Nakamura, Yoshiharu Amano, Satoshi Kojima, Takashi Hirano, Shojiro Maki, Haruki Niwa

研究成果: Article査読

73 被引用数 (Scopus)

抄録

Simple firefly luciferin analogs emitting blue, green, and red light were developed. The longest emission maximum was observed at 675 nm, which belongs to the NIR biological window (650-900 nm), useful for deep site bioimaging of living animals. The analogs showed a slow rise of emission intensity compared with the rapid emission of natural luciferin. The light emission of the adenylated analogs was strongly enhanced compared with those of analogs themselves.

本文言語English
ページ(範囲)3847-3856
ページ数10
ジャーナルTetrahedron
69
19
DOI
出版ステータスPublished - 2013 5 13

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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