Developmental biology: fgf20 is essential for initiating zebrafish fin regeneration

Geoffrey G. Whitehead, Shinji Makino, Ching Ling Lien, Mark T. Keating

研究成果: Article査読

221 被引用数 (Scopus)

抄録

Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema (dob) mutant that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema. This mutation has no impact on embryonic survival. Dob results from an fgf20a null mutation, Y148S. Fgf20a is expressed during initiation of fin regeneration at the epithelial-mesenchymal boundary and later overlaps with the blastema marker msxb. Thus, fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation.

本文言語English
ページ(範囲)1957-1960
ページ数4
ジャーナルScience
310
5756
DOI
出版ステータスPublished - 2005 12 23
外部発表はい

ASJC Scopus subject areas

  • 一般

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