Developmental biology: fgf20 is essential for initiating zebrafish fin regeneration

Geoffrey G. Whitehead, Shinji Makino, Ching Ling Lien, Mark T. Keating

研究成果: Article

191 引用 (Scopus)

抄録

Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema (dob) mutant that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema. This mutation has no impact on embryonic survival. Dob results from an fgf20a null mutation, Y148S. Fgf20a is expressed during initiation of fin regeneration at the epithelial-mesenchymal boundary and later overlaps with the blastema marker msxb. Thus, fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation.

元の言語English
ページ(範囲)1957-1960
ページ数4
ジャーナルScience
310
発行部数5756
DOI
出版物ステータスPublished - 2005 12 23
外部発表Yes

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Developmental Biology
Zebrafish
Regeneration
Mutation
Epithelium

ASJC Scopus subject areas

  • General

これを引用

Developmental biology : fgf20 is essential for initiating zebrafish fin regeneration. / Whitehead, Geoffrey G.; Makino, Shinji; Lien, Ching Ling; Keating, Mark T.

:: Science, 巻 310, 番号 5756, 23.12.2005, p. 1957-1960.

研究成果: Article

Whitehead, Geoffrey G. ; Makino, Shinji ; Lien, Ching Ling ; Keating, Mark T. / Developmental biology : fgf20 is essential for initiating zebrafish fin regeneration. :: Science. 2005 ; 巻 310, 番号 5756. pp. 1957-1960.
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