Developmental expression of the inositol 1,4,5-trisphosphate receptor and localization of inositol 1,4,5-trisphosphate during early embryogenesis in Xenopus laevis

Shoen Kume, Akira Muto, Hideyuki Okano, Katsuhiko Mikoshiba

研究成果: Article査読

31 被引用数 (Scopus)

抄録

To study the role of inositol 1,4,5-trisphosphate (IP3) receptors during early embryogenesis in Xenopus, we examined the temporal-spatial localization of Xenopus IP3 receptor (XIP3R), XIP3R protein is enriched in the animal hemisphere of early cleavage stage embryos and becomes localized in the ectoderm and involuted mesoderm in gastrula stage embryos. Up to tailbud stages, expression of XIP3R is observed in the mesodermal tissues and in most subregions of the central nervous system. A quantitative analysis of endogenous IP3 mass during normal early embryogenesis revealed an increase in IP3 mass first observed at early gastrula stage of 10.5 with an enrichment in the ectoderm throughout the gastrula stages, implying a potential role during gastrulation.

本文言語English
ページ(範囲)157-168
ページ数12
ジャーナルMechanisms of Development
66
1-2
DOI
出版ステータスPublished - 1997 8
外部発表はい

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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