Diagnosing native liver fibrosis and esophageal varices using liver and spleen stiffness measurements in biliary atresia: a pilot study

Hirofumi Tomita, Kiyoshi Ohkuma, Yohei Masugi, Naoki Hosoe, Ken Hoshino, Yasushi Fuchimoto, Akihiro Fujino, Takahiro Shimizu, Mototoshi Kato, Takumi Fujimura, Hideo Ishihama, Nobuhiro Takahashi, Yutaka Tanami, Hirotoshi Ebinuma, Hidetsugu Saito, Michiie Sakamoto, Miwako Nakano, Tatsuo Kuroda

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Background: Biliary atresia commonly leads to liver fibrosis and cirrhotic complications, including esophageal varices. Objective: To evaluate liver and spleen stiffness measurements using acoustic radiation force impulse (ARFI) imaging for diagnosing grade of liver fibrosis and predicting the presence of esophageal varices in patients treated for biliary atresia. Materials and methods: ARFI imaging of the spleen and native liver was performed in 28 patients with biliary atresia. We studied the relation between ARFI imaging values and liver histology findings (n=22), upper gastrointestinal endoscopy findings (n=16) and several noninvasive test results. Diagnostic accuracy was assessed using receiver operating characteristic curve analyses. Results: Liver stiffness measurements exhibited a significant difference among the different grades of liver fibrosis (P=0.009), and showed higher values in patients with high-risk esophageal varices than in the other patients (P=0.04). The areas under the receiver operating characteristic curves of liver stiffness measurements for liver fibrosis grades ≥ F2, ≥F3 and = F4 were 0.83, 0.93 and 0.94, respectively. Patients with high-risk esophageal varices were preferentially diagnosed by the combined liver and spleen stiffness measurements (area under the curve, 0.92). Conclusion: Liver and spleen stiffness measurements using ARFI imaging are potential noninvasive markers for liver fibrosis and esophageal varices in patients treated for biliary atresia.

本文言語English
ページ(範囲)1409-1417
ページ数9
ジャーナルPediatric Radiology
46
10
DOI
出版ステータスPublished - 2016 9 1

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 放射線学、核医学およびイメージング

フィンガープリント

「Diagnosing native liver fibrosis and esophageal varices using liver and spleen stiffness measurements in biliary atresia: a pilot study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル