Diagnosis and management of intestinal Behçet's diseas

Tadakazu Hisamatsu, Makoto Naganuma, Katsuyoshi Matsuoka, Takanori Kanai

研究成果: Review article査読

30 被引用数 (Scopus)

抄録

Behçets disease (BD) is a chronic relapsing disease with multiple organ system involvement characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmological, neurological, and/or gastrointestinal manifestations. Little clinical evidence is available regarding the management of patients with intestinal BD, despite recognition that the presence of intestinal lesions is a poor prognostic factor, causing perforation and massive bleeding. Many recent case reports have suggested that anti-tumor necrosis factor alpha (TNF)α monoclonal antibodies (mAbs) are effective in patients with intestinal BD. Adalimumab, a fully human anti-TNFα mAb, has been approved in Japan for the treatment of intestinal BD. Here, we review the pathogenesis, diagnosis and management of intestinal BD, including evidence of the efficacy of anti-TNFα mAbs.

本文言語English
ページ(範囲)205-212
ページ数8
ジャーナルClinical journal of gastroenterology
7
3
DOI
出版ステータスPublished - 2014 6月

ASJC Scopus subject areas

  • 消化器病学

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