Diastereo- and Enantioselective Iridium Catalyzed Carbonyl (α-Cyclopropyl)allylation via Transfer Hydrogenation

Ryosuke Tsutsumi, Suckchang Hong, Michael J. Krische

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The first examples of diastereo- and enantioselective carbonyl α-(cyclopropyl)allylation are reported. Under the conditions of iridium catalyzed transfer hydrogenation using the chiral precatalyst (R)-Ir-I modified by SEGPHOS, carbonyl α-(cyclopropyl)allylation may be achieved with equal facility from alcohol or aldehyde oxidation levels. This methodology provides a conduit to hitherto inaccessible inaccessible enantiomerically enriched cyclopropane-containing architectures. Alcohol solves problems: Chiral iridium catalysts modified by (R)-SEGPHOS catalyze the transfer hydrogenative coupling of racemic α-cyclopropyl allyl acetate with diverse primary alcohols with good anti-diastereo- and exceptional enantioselectivity. These processes represent the first diastereo- and enantioselective carbonyl (α-cyclopropyl)allylations.

本文言語English
ページ(範囲)12903-12907
ページ数5
ジャーナルChemistry - A European Journal
21
37
DOI
出版ステータスPublished - 2015 9月 1
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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