Diastereoselective synthesis of useful building blocks by crotylation of β-branched α-methylaldehydes with potassium crotyltrifluoroborates

Kyosuke Tanaka, Yukiko Fujimori, Yoko Saikawa, Masaya Nakata

研究成果: Article査読

12 被引用数 (Scopus)

抄録

(Chemical Equation Presented) The diastereoselective construction of stereotriads having consecutive methyl, hydroxy, and methyl substituents was realized by the substrate-controlled crotylation of β-branched α-methylaldehydes with potassium crotyltrifluoroborates. Especially, crotylation of 2-(1,3-dithian-2-yl)propanal with potassium (E)- crotyltrifluoroborate afforded, in good yield and with excellent diastereoselectivity, a useful building block that has different and potential functional groups on both ends.

本文言語English
ページ(範囲)6292-6298
ページ数7
ジャーナルJournal of Organic Chemistry
73
16
DOI
出版ステータスPublished - 2008 8 15

ASJC Scopus subject areas

  • 有機化学

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