Diastereoselective synthesis of useful building blocks by crotylation of β-branched α-methylaldehydes with potassium crotyltrifluoroborates

Kyosuke Tanaka, Yukiko Fujimori, Yoko Saikawa, Masaya Nakata

研究成果: Article

11 引用 (Scopus)

抜粋

(Chemical Equation Presented) The diastereoselective construction of stereotriads having consecutive methyl, hydroxy, and methyl substituents was realized by the substrate-controlled crotylation of β-branched α-methylaldehydes with potassium crotyltrifluoroborates. Especially, crotylation of 2-(1,3-dithian-2-yl)propanal with potassium (E)- crotyltrifluoroborate afforded, in good yield and with excellent diastereoselectivity, a useful building block that has different and potential functional groups on both ends.

元の言語English
ページ(範囲)6292-6298
ページ数7
ジャーナルJournal of Organic Chemistry
73
発行部数16
DOI
出版物ステータスPublished - 2008 8 15

ASJC Scopus subject areas

  • Organic Chemistry

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