TY - JOUR
T1 - Diet, microbiota, and inflammatory bowel disease
T2 - Lessons from Japanese foods
AU - Kanai, Takanori
AU - Matsuoka, Katsuyoshi
AU - Naganuma, Makoto
AU - Hayashi, Atsushi
AU - Hisamatsu, Tadakazu
PY - 2014
Y1 - 2014
N2 - The incidence and prevalence of inflammatory bowel diseases (IBDs) including ulcerative colitis and Crohn disease are rapidly increasing in Western countries and in developed Asian countries. Although biologic agents targeting the immune system have been effective in patients with IBD, cessation of treatment leads to relapse in the majority of patients, suggesting that intrinsic immune dysregulation is an effect, not a cause, of IBD. Dramatic changes in the environment, resulting in the dysregulated composition of intestinal microbiota or dysbiosis, may be associated with the fundamental causes of IBD. Japan now has upgraded water supply and sewerage systems, as well as dietary habits and antibiotic overuse that are similar to such features found in developed Western countries. The purpose of this review article was to describe the association of diet, particularly Japanese food and microbiota, with IBD.
AB - The incidence and prevalence of inflammatory bowel diseases (IBDs) including ulcerative colitis and Crohn disease are rapidly increasing in Western countries and in developed Asian countries. Although biologic agents targeting the immune system have been effective in patients with IBD, cessation of treatment leads to relapse in the majority of patients, suggesting that intrinsic immune dysregulation is an effect, not a cause, of IBD. Dramatic changes in the environment, resulting in the dysregulated composition of intestinal microbiota or dysbiosis, may be associated with the fundamental causes of IBD. Japan now has upgraded water supply and sewerage systems, as well as dietary habits and antibiotic overuse that are similar to such features found in developed Western countries. The purpose of this review article was to describe the association of diet, particularly Japanese food and microbiota, with IBD.
KW - Diet
KW - Inflammatory bowel diseases
KW - Japanese food
KW - Microbiota
KW - Probiotics
UR - http://www.scopus.com/inward/record.url?scp=84904580403&partnerID=8YFLogxK
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U2 - 10.3904/kjim.2014.29.4.409
DO - 10.3904/kjim.2014.29.4.409
M3 - Review article
C2 - 25045286
AN - SCOPUS:84904580403
VL - 29
SP - 409
EP - 415
JO - Korean Journal of Internal Medicine
JF - Korean Journal of Internal Medicine
SN - 0494-4712
IS - 4
ER -