Difference in gene expression for matrix metalloproteinase-1 between early and advanced hepatocellular carcinomas

Isao Okazaki, Norihito Wada, Masayuki Nakano, Akiko Saito, Ken Takasaki, Mikio Doi, Kaori Kameyama, Yoshihide Otani, Kiyoshi Kubochi, Maki Niioka, Tetsu Watanabe, Katsuya Maruyama

研究成果: Article査読

46 被引用数 (Scopus)

抄録

The histological observation that well-differentiated cancer cells in early hepatocellular carcinoma (HCC) invade portal tracts and/or fibrous hands and that these fibrous tissues then disappear suggests the participation of matrix metalloproteinase-1 (MMP-1) in the degradation of fibrous tissue. To confirm this hypothesis, the authors investigated the localization of both the MMP-1 protein and its messenger RNA (mRNA) in early HCC immunohistochemically and by in situ hybridization using complementary DNA (cDNA) and synthetic antisense probe of MMP-1; they then compared the results with those in advanced HCC. MMP-1 gene transcripts and protein were observed in well-differentiated cancer cells of early HCC but not in moderately or poorly differentiated cancer cells. Thus, cancer cells producing MMP-1 in early HCC may destroy the portal tract tissue adjacent to the cancer lesion and/or the fibrous band of cirrhosis. These results seem to have demonstrated a difference in the mechanism of cancer growth and invasion between early and advanced HCCs.

本文言語English
ページ(範囲)580-584
ページ数5
ジャーナルHepatology
25
3
DOI
出版ステータスPublished - 1997
外部発表はい

ASJC Scopus subject areas

  • 肝臓学

フィンガープリント

「Difference in gene expression for matrix metalloproteinase-1 between early and advanced hepatocellular carcinomas」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル