Difference in the recurrence rate between right- and left-sided colon cancer: A 17-year experience at a single institution

Konosuke Moritani, Hirotoshi Hasegawa, Koji Okabayashi, Yoshiyuki Ishii, Takashi Endo, Yuukou Kitagawa

研究成果: Article

30 引用 (Scopus)

抄録

Purpose: The prognostic differences between right- and left-sided colon cancer are controversial. This study aimed to clarify the clinical difference between right- and left-sided colon cancer. Methods: We enrolled 820 patients with stage I/II/III colon cancer who underwent radical surgery with curative intent. We explored the impact of the tumor location on the postoperative disease-free survival (DFS) rate using the univariate and multivariate analyses. Results: Right-sided disease occurred in 399 of the 820 patients. The mean follow-up period was 55.8 ± 34.9 months. The pathological stage distribution was as follows: stage I 261 patients; stage II 283; and stage III 251. There were no significant differences in the five-year DFS of the overall populations (right 88.6 %; left 89.4 %; P = 0.231). The subgroup analyses demonstrated that patients with stage I right-sided colon cancer had a significantly better 5-year DFS rate than did those with left-sided disease (100 vs. 95.2 %, P = 0.034). There were no significant differences in the distributions of the first recurrent sites (P = 0.559). Conclusions: The tumor location may contribute to postoperative tumor recurrence. However, these effects were inconsistent across tumor stages. Our results provide a better understanding of the prognostic disparity between tumor locations; this may improve patient consent and postoperative surveillance.

元の言語English
ページ(範囲)1685-1691
ページ数7
ジャーナルSurgery Today
44
発行部数9
DOI
出版物ステータスPublished - 2014

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A 17
Colonic Neoplasms
Recurrence
Disease-Free Survival
Neoplasms
Survival Rate
Multivariate Analysis
Population

ASJC Scopus subject areas

  • Surgery

これを引用

Difference in the recurrence rate between right- and left-sided colon cancer : A 17-year experience at a single institution. / Moritani, Konosuke; Hasegawa, Hirotoshi; Okabayashi, Koji; Ishii, Yoshiyuki; Endo, Takashi; Kitagawa, Yuukou.

:: Surgery Today, 巻 44, 番号 9, 2014, p. 1685-1691.

研究成果: Article

Moritani, Konosuke ; Hasegawa, Hirotoshi ; Okabayashi, Koji ; Ishii, Yoshiyuki ; Endo, Takashi ; Kitagawa, Yuukou. / Difference in the recurrence rate between right- and left-sided colon cancer : A 17-year experience at a single institution. :: Surgery Today. 2014 ; 巻 44, 番号 9. pp. 1685-1691.
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abstract = "Purpose: The prognostic differences between right- and left-sided colon cancer are controversial. This study aimed to clarify the clinical difference between right- and left-sided colon cancer. Methods: We enrolled 820 patients with stage I/II/III colon cancer who underwent radical surgery with curative intent. We explored the impact of the tumor location on the postoperative disease-free survival (DFS) rate using the univariate and multivariate analyses. Results: Right-sided disease occurred in 399 of the 820 patients. The mean follow-up period was 55.8 ± 34.9 months. The pathological stage distribution was as follows: stage I 261 patients; stage II 283; and stage III 251. There were no significant differences in the five-year DFS of the overall populations (right 88.6 {\%}; left 89.4 {\%}; P = 0.231). The subgroup analyses demonstrated that patients with stage I right-sided colon cancer had a significantly better 5-year DFS rate than did those with left-sided disease (100 vs. 95.2 {\%}, P = 0.034). There were no significant differences in the distributions of the first recurrent sites (P = 0.559). Conclusions: The tumor location may contribute to postoperative tumor recurrence. However, these effects were inconsistent across tumor stages. Our results provide a better understanding of the prognostic disparity between tumor locations; this may improve patient consent and postoperative surveillance.",
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AU - Ishii, Yoshiyuki

AU - Endo, Takashi

AU - Kitagawa, Yuukou

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N2 - Purpose: The prognostic differences between right- and left-sided colon cancer are controversial. This study aimed to clarify the clinical difference between right- and left-sided colon cancer. Methods: We enrolled 820 patients with stage I/II/III colon cancer who underwent radical surgery with curative intent. We explored the impact of the tumor location on the postoperative disease-free survival (DFS) rate using the univariate and multivariate analyses. Results: Right-sided disease occurred in 399 of the 820 patients. The mean follow-up period was 55.8 ± 34.9 months. The pathological stage distribution was as follows: stage I 261 patients; stage II 283; and stage III 251. There were no significant differences in the five-year DFS of the overall populations (right 88.6 %; left 89.4 %; P = 0.231). The subgroup analyses demonstrated that patients with stage I right-sided colon cancer had a significantly better 5-year DFS rate than did those with left-sided disease (100 vs. 95.2 %, P = 0.034). There were no significant differences in the distributions of the first recurrent sites (P = 0.559). Conclusions: The tumor location may contribute to postoperative tumor recurrence. However, these effects were inconsistent across tumor stages. Our results provide a better understanding of the prognostic disparity between tumor locations; this may improve patient consent and postoperative surveillance.

AB - Purpose: The prognostic differences between right- and left-sided colon cancer are controversial. This study aimed to clarify the clinical difference between right- and left-sided colon cancer. Methods: We enrolled 820 patients with stage I/II/III colon cancer who underwent radical surgery with curative intent. We explored the impact of the tumor location on the postoperative disease-free survival (DFS) rate using the univariate and multivariate analyses. Results: Right-sided disease occurred in 399 of the 820 patients. The mean follow-up period was 55.8 ± 34.9 months. The pathological stage distribution was as follows: stage I 261 patients; stage II 283; and stage III 251. There were no significant differences in the five-year DFS of the overall populations (right 88.6 %; left 89.4 %; P = 0.231). The subgroup analyses demonstrated that patients with stage I right-sided colon cancer had a significantly better 5-year DFS rate than did those with left-sided disease (100 vs. 95.2 %, P = 0.034). There were no significant differences in the distributions of the first recurrent sites (P = 0.559). Conclusions: The tumor location may contribute to postoperative tumor recurrence. However, these effects were inconsistent across tumor stages. Our results provide a better understanding of the prognostic disparity between tumor locations; this may improve patient consent and postoperative surveillance.

KW - Colon carcinoma

KW - Distal colon

KW - Prognosis

KW - Proximal colon

KW - Recurrence

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