We investigated the differences in Fourier transform-infrared (FT-IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU-1, and NCI-N87) showed a significant increase in infrared absorption in the band around 1240 cm-1, 1120 cm-1 and 1080 cm-1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm-1 and 3.8 cm-1 were seen at the peak absorbance in the bands around 1240 cm-1 and 1080 cm-1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT-IR spectroscopy is a potential new tool for gastric cancer diagnosis.
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