Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cord

Masaya Nakamura, Richard A. Houghtling, Linda MacArthur, Barbara M. Bayer, Barbara S. Bregman

研究成果: Article査読

134 被引用数 (Scopus)

抄録

It is likely that the environment within the injured spinal cord influences the capacity of fetal spinal cord transplants to support axonal growth. We have recently demonstrated that fetal spinal cord transplants and neurotrophin administration support axonal regeneration after spinal cord transection, and that the distance and amount of axonal growth is greater when these treatments are delayed by several weeks after injury (Coumans et al., 2001). In this study, we sought to determine whether differences in inflammatory mediators exist between the acutely injured spinal cord and the spinal cord after a second injury and re-section, which could provide a more favorable environment for the axonal re-growth. The results of this study show a more rapid induction of transforming growth factor (TGF) β1 mRNA expression in the re-injured spinal cord than the acutely injured spinal cord and an attenuation of proinflammatory cytokine mRNA expression. Furthermore, there was a rapid recruitment of activated microglia/macrophages in the degenerating white matter rostral and caudal to the injury but fewer within the lesion site itself. These findings suggest that the augmentation of TGFβ-1 gene expression and the attenuation of pro-inflammatory cytokine gene expression combined with an altered distribution of activated microglia/macrophages in the re-injured spinal cord might create a more favorable milieu for transplants and axonal regrowth as compared to the acutely injured spinal cord.

本文言語English
ページ(範囲)313-325
ページ数13
ジャーナルExperimental Neurology
184
1
DOI
出版ステータスPublished - 2003 11

ASJC Scopus subject areas

  • 神経学
  • 発達神経科学

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