Different chemo- and endocrino- sensitivity of MCF-7 cells with or without estradiol supplement in vitro

H. Tanino, T. Kubota, Yoshirou Saikawa, T. H. Kuo, T. Takeuchi, S. Kase, T. Furukawa, M. Kitajima, T. Sakurai, Y. Naito, R. M. Hoffman

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The sensitivity of MCF-7 cells to tamoxifen (TAM) and mitomycin C (MMC) was assessed in rapidly and slowly growing cells with or without estradiol supplementation, respectively. The growth of MCF-7 was inhibited by MMC in a concentration-dependent manner with or without estradiol (E2) supplementation. Preincubation with MMC suppressed subsequent E2 stimulated growth of MCF-7. TAM inhibited the growth of MCF-7 supplemented with E2, and preincubation with TAM prevented subsequent E2 stimulated growth of MCF-7. However, TAM did not inhibit the growth of MCF-7 cells in E2 free medium. These results suggested that MMC may be more effective than TAM on breast cancer cells in the dormant or slow-growth phase.

本文言語English
ページ(範囲)1219-1221
ページ数3
ジャーナルAnticancer research
13
4
出版ステータスPublished - 1993 1 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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