Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis

Naoki Ichinose, Gakushi Yoshikawa, Eri Fukao, Mai Ichisawa, Tomoaki Takahata, Yuki Enoki, Kazuaki Taguchi, Toshimi Oda, Kazuo Tsutsumi, Kazuaki Matsumoto

研究成果: Article査読

抄録

Linezolid has excellent antibiotic activity against gram-positive organisms and is expected to be an alternative to vancomycin for the treatment of bacterial meningitis. Accumulated evidence has shown the superior pharmacokinetic characteristics of linezolid to vancomycin, such as cerebrospinal fluid penetration. However, in the treatment of meningitis, pharmacokinetic information regarding the intra-cerebrospinal distribution of linezolid and the effects of drainage on the linezolid concentration in the cerebrospinal fluid are unclear. This report describes two patient cases, in which the linezolid concentrations in the cerebrospinal fluid were in the following order: subarachnoid space (cisternal drainage and lumbar puncture) ≥ third ventricle > lateral ventricle. In addition, the linezolid concentration in the cerebrospinal fluid, collected via lumbar puncture, tended to increase after removal of the drainage. This report is novel in presenting two cases of meningitis that showed different intra-cerebrospinal distribution of linezolid in various parts of the central nervous system and an increased linezolid concentration in the cerebrospinal fluid after removal of the drainage.

本文言語English
ページ(範囲)382-384
ページ数3
ジャーナルInternational Journal of Infectious Diseases
110
DOI
出版ステータスPublished - 2021 9

ASJC Scopus subject areas

  • 微生物学(医療)
  • 感染症

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