Different mutations of the p53 gene in nodule-in-nodule hepatocellular carcinoma as a evidence for multistage progression

Tatsuya Oda, Hitoshi Tsuda, Michiie Sakamoto, Setsuo Hirohashi

研究成果: Article査読

51 被引用数 (Scopus)

抄録

The p53 gene was analysed for mutation in three macro- and micro-scopically different areas of a nodule-in-nodule hepatocellular carcinoma (HCC). Two inner nodules revealed distinct mutations, while the surrounding early HCC lesion was negative for mutation. This case clearly demonstrated that the p53 mutation was associated with the progression of HCC from an early to a more advanced stage, and that the primary HCC lesion was composed of genetically heterogeneous subclones. These findings provide direct proof of the involvement of genetic abnormalities in one step of multistage tumor progression.

本文言語English
ページ(範囲)197-200
ページ数4
ジャーナルCancer Letters
83
1-2
DOI
出版ステータスPublished - 1994 8月 15
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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