抄録
The hypothesis that glutamate is the afferent transmitter in the acoustico-lateralis receptors was examined in Plotosus electroreceptors. JSTX, a spider toxin known to specifically block glutamate receptors, irreversibly abolished afferent impulse discharges induced by iontophoretically applied glutamate, whereas those induced synaptically by focal stimulation of receptor cells were little affected. Such differential blocking effects by JSTX, complementary to other biochemical data, further provide pharmacological evidence against the glutamate hypothesis.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 183-187 |
| ページ数 | 5 |
| ジャーナル | Brain Research |
| 巻 | 300 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | Published - 1984 5 21 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
これを引用
Differential blocking effects of a spider toxin on synaptic and glutamate responses in the afferent synapse of the acoustico-lateralis receptors of Plotosus. / Nagai, Takatoshi; Obara, Shosaku; Kawai, Nobufumi.
：: Brain Research, 巻 300, 番号 1, 21.05.1984, p. 183-187.研究成果: Article
}
TY - JOUR
T1 - Differential blocking effects of a spider toxin on synaptic and glutamate responses in the afferent synapse of the acoustico-lateralis receptors of Plotosus
AU - Nagai, Takatoshi
AU - Obara, Shosaku
AU - Kawai, Nobufumi
PY - 1984/5/21
Y1 - 1984/5/21
N2 - The hypothesis that glutamate is the afferent transmitter in the acoustico-lateralis receptors was examined in Plotosus electroreceptors. JSTX, a spider toxin known to specifically block glutamate receptors, irreversibly abolished afferent impulse discharges induced by iontophoretically applied glutamate, whereas those induced synaptically by focal stimulation of receptor cells were little affected. Such differential blocking effects by JSTX, complementary to other biochemical data, further provide pharmacological evidence against the glutamate hypothesis.
AB - The hypothesis that glutamate is the afferent transmitter in the acoustico-lateralis receptors was examined in Plotosus electroreceptors. JSTX, a spider toxin known to specifically block glutamate receptors, irreversibly abolished afferent impulse discharges induced by iontophoretically applied glutamate, whereas those induced synaptically by focal stimulation of receptor cells were little affected. Such differential blocking effects by JSTX, complementary to other biochemical data, further provide pharmacological evidence against the glutamate hypothesis.
KW - acoustico-lateralis receptor
KW - afferent synapse
KW - glutamate receptor
KW - iontophoresis
KW - neurotransmitter
KW - spider toxin
UR - http://www.scopus.com/inward/record.url?scp=0021282077&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021282077&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(84)91357-X
DO - 10.1016/0006-8993(84)91357-X
M3 - Article
C2 - 6145500
AN - SCOPUS:0021282077
VL - 300
SP - 183
EP - 187
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -