TY - JOUR
T1 - Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma
T2 - A case report of an elderly man
AU - Takahashi, Kenta
AU - Tsuda, Masumi
AU - Kanno, Hiromi
AU - Murata, Junichi
AU - Mahabir, Roshan
AU - Ishida, Yusuke
AU - Kimura, Taichi
AU - Tanino, Mishie
AU - Nishihara, Hiroshi
AU - Nagashima, Kazuo
AU - Tanaka, Shinya
N1 - Funding Information:
We thank Eiko Aoyanagi, Miho Nodagashira, Shiori Akesaka, Mami Sato and Kazuko Shimizu for their excellent technique. This study is supported by the grant from Ministry of Education, Culture, Sports, Science and Technology-Japan.
PY - 2014/4
Y1 - 2014/4
N2 - Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to differentiate from anaplastic oligodendroglioma. In this report, we present a case of small cell glioblastoma of an elderly man. The lack of IDH1/2 mutation was confirmed by immunohistochemistry and direct sequencing. Fluorescence in situ hybridization revealed the lower rates of chromosome 1p and 19q deletion. Microsatellite analysis disclosed partial 10q alteration near the PTEN locus. Not only morphological and immunohistochemical examinations, but also cytogenetical investigations for IDH1/2 mutation, 1p/19q loss, and PTEN alteration, are strongly supportive methods for the differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma.
AB - Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to differentiate from anaplastic oligodendroglioma. In this report, we present a case of small cell glioblastoma of an elderly man. The lack of IDH1/2 mutation was confirmed by immunohistochemistry and direct sequencing. Fluorescence in situ hybridization revealed the lower rates of chromosome 1p and 19q deletion. Microsatellite analysis disclosed partial 10q alteration near the PTEN locus. Not only morphological and immunohistochemical examinations, but also cytogenetical investigations for IDH1/2 mutation, 1p/19q loss, and PTEN alteration, are strongly supportive methods for the differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma.
KW - 1p/19q loss
KW - Anaplastic oligodendroglioma
KW - IDH1 mutation
KW - PTEN alteration
KW - Small cell glioblastoma
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U2 - 10.1007/s10014-013-0158-9
DO - 10.1007/s10014-013-0158-9
M3 - Article
C2 - 23979650
AN - SCOPUS:84899910809
SN - 1433-7398
VL - 31
SP - 118
EP - 123
JO - Brain Tumor Pathology
JF - Brain Tumor Pathology
IS - 2
ER -
