Differential effects on expression of IL‐2 receptors (p55 and p70) by the HTLV‐I pX DNA

Hisataka Sabe, Atsushi Tanaka, Haruhiko Siomi, Shigeo Koyasu, Shin Yonehara, Ichiro Yahara, Yutaka Tagaya, Katsuji Sugie, Keisuke Teshigawara, Junji Yodoi, Masakazu Hatanaka

研究成果: Article

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Abnormal expression of the low‐affinity receptor for inter‐leukin‐2 (IL‐2R) is a characteristic of the HTLV‐I (+) leukemic T cells in adult T‐cell leukemia (ATL). Despite the expression of IL‐2R bearing Tac antigen (IL‐2R/pSS), leukemic cells of the majority of ATL patients do not proliferate in response to IL‐2. In the human NK cell line, YT, as well as in ATL‐derived T cells, the co‐expression of IL‐2R/p55 and the second IL‐2R without the Tac epitope (IL‐2R/p70) is required to produce high‐affinity IL‐2R. To study the effect of HTLV‐I on both of the IL‐2Rs, we transferred a fragment of HTLV‐I containing the p40X gene into YT cells. One of the 2 transfected YT clones (YT/pX‐5.1) had an increased level of expression of IL‐2R/p55. In contrast, expression of (L‐2R/p70 was unaffected, as determined by Scatchard analysis and the cross‐linking study using 125‐IL‐2. Our results show that the T‐cell phenotype is not required for induction of IL‐2R/p55 by p40X. We suggest that HTLV‐I infection induces a disproportionate induction of IL‐2R/pSS without significant enhancement of IL‐2R/p70 expression, resulting in the predominant expression of low‐affintty IL‐2R in ATL. IL‐2R/p70 may be a critical parameter determining the IL‐2 reactivity of HTLV‐I‐infected T cells as well as of normal lymphocytes.

元の言語English
ページ(範囲)880-885
ページ数6
ジャーナルInternational Journal of Cancer
41
発行部数6
DOI
出版物ステータスPublished - 1988 6 15
外部発表Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Sabe, H., Tanaka, A., Siomi, H., Koyasu, S., Yonehara, S., Yahara, I., Tagaya, Y., Sugie, K., Teshigawara, K., Yodoi, J., & Hatanaka, M. (1988). Differential effects on expression of IL‐2 receptors (p55 and p70) by the HTLV‐I pX DNA. International Journal of Cancer, 41(6), 880-885. https://doi.org/10.1002/ijc.2910410619