Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region

Maurizio D'Esposito, Maria Rosaria Matarazzo, Alfredo Ciccodicola, Maria Strazzullo, Richard Mazzarella, Nandita A. Quaderi, Hiroyuki Fujiwara, Minoru S.H. Ko, Lucy B. Rowe, Angela Ricco, Nicoletta Archidiacono, Mariano Rocchi, David Schlessinger, Michele D'Urso

研究成果: Article査読

22 被引用数 (Scopus)

抄録

The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1. Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y. Here we show that differences are also seen in the evolution of the sex chromosome locations of IL9R and SYBL1, IL9R is known to be autosomal in mice, and is X-linked only in primates. SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans. Both genes were duplicated on the Y homologue of the terminal portion of the X chromosome during the evolution of Homo sapiens from other higher primates. The inactivation pattern of SYBL1 may be correlated with its longer history of X linkage, and at a more centromeric chromosomal position during evolution; the more recent X linkage and more telomeric position of the IL9R gene may explain its autosomal, 'uninactivated' transcriptional status.

本文言語English
ページ(範囲)1917-1923
ページ数7
ジャーナルHuman molecular genetics
6
11
DOI
出版ステータスPublished - 1997 10月
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • 遺伝学(臨床)

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