Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region

Maurizio D'Esposito, Maria Rosaria Matarazzo, Alfredo Ciccodicola, Maria Strazzullo, Richard Mazzarella, Nandita A. Quaderi, Hiroyuki Fujiwara, Minoru Ko, Lucy B. Rowe, Angela Ricco, Nicoletta Archidiacono, Mariano Rocchi, David Schlessinger, Michele D'Urso

研究成果: Article

21 引用 (Scopus)

抄録

The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1. Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y. Here we show that differences are also seen in the evolution of the sex chromosome locations of IL9R and SYBL1, IL9R is known to be autosomal in mice, and is X-linked only in primates. SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans. Both genes were duplicated on the Y homologue of the terminal portion of the X chromosome during the evolution of Homo sapiens from other higher primates. The inactivation pattern of SYBL1 may be correlated with its longer history of X linkage, and at a more centromeric chromosomal position during evolution; the more recent X linkage and more telomeric position of the IL9R gene may explain its autosomal, 'uninactivated' transcriptional status.

元の言語English
ページ(範囲)1917-1923
ページ数7
ジャーナルHuman Molecular Genetics
6
発行部数11
DOI
出版物ステータスPublished - 1997 10
外部発表Yes

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X Chromosome
Primates
Genes
Marsupialia
X Chromosome Inactivation
X-Linked Genes
Sex Chromosomes
Gene Order
Mammals
Alleles

ASJC Scopus subject areas

  • Genetics

これを引用

D'Esposito, M., Matarazzo, M. R., Ciccodicola, A., Strazzullo, M., Mazzarella, R., Quaderi, N. A., ... D'Urso, M. (1997). Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. Human Molecular Genetics, 6(11), 1917-1923. https://doi.org/10.1093/hmg/6.11.1917

Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. / D'Esposito, Maurizio; Matarazzo, Maria Rosaria; Ciccodicola, Alfredo; Strazzullo, Maria; Mazzarella, Richard; Quaderi, Nandita A.; Fujiwara, Hiroyuki; Ko, Minoru; Rowe, Lucy B.; Ricco, Angela; Archidiacono, Nicoletta; Rocchi, Mariano; Schlessinger, David; D'Urso, Michele.

:: Human Molecular Genetics, 巻 6, 番号 11, 10.1997, p. 1917-1923.

研究成果: Article

D'Esposito, M, Matarazzo, MR, Ciccodicola, A, Strazzullo, M, Mazzarella, R, Quaderi, NA, Fujiwara, H, Ko, M, Rowe, LB, Ricco, A, Archidiacono, N, Rocchi, M, Schlessinger, D & D'Urso, M 1997, 'Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region', Human Molecular Genetics, 巻. 6, 番号 11, pp. 1917-1923. https://doi.org/10.1093/hmg/6.11.1917
D'Esposito, Maurizio ; Matarazzo, Maria Rosaria ; Ciccodicola, Alfredo ; Strazzullo, Maria ; Mazzarella, Richard ; Quaderi, Nandita A. ; Fujiwara, Hiroyuki ; Ko, Minoru ; Rowe, Lucy B. ; Ricco, Angela ; Archidiacono, Nicoletta ; Rocchi, Mariano ; Schlessinger, David ; D'Urso, Michele. / Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. :: Human Molecular Genetics. 1997 ; 巻 6, 番号 11. pp. 1917-1923.
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abstract = "The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1. Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y. Here we show that differences are also seen in the evolution of the sex chromosome locations of IL9R and SYBL1, IL9R is known to be autosomal in mice, and is X-linked only in primates. SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans. Both genes were duplicated on the Y homologue of the terminal portion of the X chromosome during the evolution of Homo sapiens from other higher primates. The inactivation pattern of SYBL1 may be correlated with its longer history of X linkage, and at a more centromeric chromosomal position during evolution; the more recent X linkage and more telomeric position of the IL9R gene may explain its autosomal, 'uninactivated' transcriptional status.",
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AU - Ricco, Angela

AU - Archidiacono, Nicoletta

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