TY - JOUR
T1 - Differential Localization of Alternative Spliced Transcripts Encoding Inositol 1,4,5‐Trisphosphate Receptors in Mouse Cerebellum and Hippocampus
T2 - In Situ Hybridization Study
AU - Nakagawa, Toshiyuki
AU - Shiota, Chiyo
AU - Okano, Hideyuki
AU - Mikoshiba, Katsuhiko
PY - 1991/11
Y1 - 1991/11
N2 - : Expression of inositol 1,4,5‐trisphosphate (InsP3) receptor subtypes was determined in mouse brain using oligonucleotide‐specific in situ hybridization. All subtypes, except one that deletes 120 bp from the full‐length InsP3 receptor cDNA, were expressed in cerebellar Purkinje cells. In hippocampus, various subtypes showed distinct expression patterns. These results suggest that regionally selective expression of InsP3 receptor subtypes may result in the generation of functionally distinct channels.
AB - : Expression of inositol 1,4,5‐trisphosphate (InsP3) receptor subtypes was determined in mouse brain using oligonucleotide‐specific in situ hybridization. All subtypes, except one that deletes 120 bp from the full‐length InsP3 receptor cDNA, were expressed in cerebellar Purkinje cells. In hippocampus, various subtypes showed distinct expression patterns. These results suggest that regionally selective expression of InsP3 receptor subtypes may result in the generation of functionally distinct channels.
KW - Alternative splicing
KW - Cerebellum
KW - Hippocampus
KW - In situ hybridization
KW - Inositol 1,4,5‐trisphosphate receptor
KW - Mouse brain
KW - Purkinje cell
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U2 - 10.1111/j.1471-4159.1991.tb06385.x
DO - 10.1111/j.1471-4159.1991.tb06385.x
M3 - Article
C2 - 1655981
AN - SCOPUS:0025989363
VL - 57
SP - 1807
EP - 1810
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 5
ER -