Differential Prevalence of HIV Type 1 Subtype B and CRF01_AE among Different Sexual Transmission Groups in Tokyo, Japan, as Revealed by Subtype-Specific PCR

Shingo Kato, Yuki Saito, Rie Tanaka, Yoshiyuki Hiraishi, Naoto Kitamura, Tomoko Matsumoto, Hideji Hanabusa, Mitsuhiro Kamakura, Yasuo Ikeda, Masayoshi Negishi

研究成果: Review article査読

17 被引用数 (Scopus)

抄録

We determined the subtype of HIV-1 in 89 infected individuals attending three reference hospitals located in the Tokyo metropolitan area of Japan. Subtyping was performed with subtype-specific polymerase chain reaction (PCR) distinguishing subtype A, B, C, and CRF01_AE and/or phylogenetic analysis of HIV-1 env C2V3C3 sequences. Subtype-specific PCR provided unequivocal results in 97% of samples. Sixty-five subjects were infected with subtype B, 16 with CRF01_AE, 4 with subtype A, 1 with CRF02_AG, and 3 with subtype C. Among 31 Japanese individuals infected through heterosexual contact, 13 were infected with subtype B and 12 with CRF01_AE. All of the 41 Japanese men infected through homosexual contact harbored subtype B. These results indicate that subtype B is exclusively predominant in a homosexually transmitted group, whereas subtype B and CRF01_AE are evenly predominant in a heterosexually transmitted group.

本文言語English
ページ(範囲)1057-1063
ページ数7
ジャーナルAIDS Research and Human Retroviruses
19
11
DOI
出版ステータスPublished - 2003 11 1

ASJC Scopus subject areas

  • 免疫学
  • ウイルス学
  • 感染症

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