Differentiation, polarization, and migration of human induced pluripotent stem cell-derived neural progenitor cells co-cultured with a human glial cell line with radial glial-like characteristics

Yohei Bamba, Tomoko Shofuda, Daisuke Kanematsu, Masahiro Nonaka, Mami Yamasaki, Hideyuki Okano, Yonehiro Kanemura

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Here we established a unique human glial cell line, GDC90, derived from a human glioma and demonstrated its utility as a glial scaffold for the polarization and differentiation of human induced pluripotent stem cell-derived neural progenitor cells (iPSC-NPCs). When co-cultured with GDC90 cells, iPSC-NPCs underwent rapid polarization and neurite extension along the radially spreading processes of the GDC90 cells, and showed migratory behavior. This method is potentially useful for detailed examination of neurites or for controlling neurites behavior for regenerative medicine.

本文言語English
ページ(範囲)683-688
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
447
4
DOI
出版ステータスPublished - 2014 5月 16

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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