Diphenylprolinol silyl ethers as efficient organocatalysts for the asymmetric Michael reaction of aldehydes and nitroalkenes

Yujiro Hayashi, Hiroaki Gotoh, Takaaki Hayashi, Mitsuru Shoji

研究成果: Article査読

1044 被引用数 (Scopus)

抄録

(Chemical Equation Presented) The direct, catalytic, asymmetric Michael addition of aldehydes to nitroolefins in the presence of a chiral diphenylprolinol silyl ether organocatalyst is described (see scheme). The desired 1,4-addition products were obtained in nearly optically pure form in good yield with high syn diastereoselectivity. TMS = trimethylsilyl.

本文言語English
ページ(範囲)4212-4215
ページ数4
ジャーナルAngewandte Chemie - International Edition
44
27
DOI
出版ステータスPublished - 2005 7 4

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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