Direct Catalytic Asymmetric 1,6-Conjugate Addition of Amides to p-Quinone Methides

Zhongdong Sun, Bo Sun, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Amide pronucleophiles were successfully incorporated into a 1,6-conjugate addition reaction manifold using p-quinone methides (p-QMs) as electrophiles. Four different types of functionalities were tolerated as α-substituents of the amides, allowing for expeditious access to a range of enantiomerically enriched diarylmethine products. The 7-azaindoline unit is critically important for in situ catalytic enolization of the amide pronucleophile, engaging in 1,6-conjugate addition to p-QMs with readily available catalyst components.

本文言語English
ページ(範囲)3070-3073
ページ数4
ジャーナルOrganic Letters
20
10
DOI
出版ステータスPublished - 2018 5 18
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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