Direct Catalytic Asymmetric Addition of Alkylnitriles to Aldehydes with Designed Nickel–Carbene Complexes

Akira Saito, Shinya Adachi, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

5 被引用数 (Scopus)

抄録

A direct catalytic asymmetric addition of acetonitrile to aldehydes that realizes over 90 % ee is the ultimate challenge in alkylnitrile addition chemistry. Herein, we report achieving high enantioselectivity by the strategic use of a sterically demanding NiII pincer carbene complex, which afforded highly enantioenriched β-hydroxynitriles. This highly atom-economical process paves the way for exploiting inexpensive acetonitrile as a promising C2 building block in a practical synthetic toolbox for asymmetric catalysis.

本文言語English
ページ(範囲)8739-8743
ページ数5
ジャーナルAngewandte Chemie - International Edition
60
16
DOI
出版ステータスPublished - 2021 4月 12
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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