@article{d068b3fdb60f4a2a9ef11f7adcbd887d,
title = "Direct Catalytic Asymmetric Addition of Alkylnitriles to Aldehydes with Designed Nickel–Carbene Complexes",
abstract = "A direct catalytic asymmetric addition of acetonitrile to aldehydes that realizes over 90 % ee is the ultimate challenge in alkylnitrile addition chemistry. Herein, we report achieving high enantioselectivity by the strategic use of a sterically demanding NiII pincer carbene complex, which afforded highly enantioenriched β-hydroxynitriles. This highly atom-economical process paves the way for exploiting inexpensive acetonitrile as a promising C2 building block in a practical synthetic toolbox for asymmetric catalysis.",
keywords = "aldehydes, enantioselectivity, homogeneous catalysis, nickel, nitriles",
author = "Akira Saito and Shinya Adachi and Naoya Kumagai and Masakatsu Shibasaki",
note = "Funding Information: This work was financially supported by JSPS KAKENHI Grant Number JP20H03371 (Grant-in-Aid for Scientific Research (B)) to M.S., and JP19K22192 (Grant-in-Aid for Exploratory Research) and JP20H02746 (Grant-in-Aid for Scientific Research (B)) to N.K. We are grateful to Dr. Ryuichi Sawa, Ms. Yumiko Kubota, and Dr. Kiyoko Iijima at the Institute of Microbial Chemistry for technical support in NMR. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",
year = "2021",
month = apr,
day = "12",
doi = "10.1002/anie.202016690",
language = "English",
volume = "60",
pages = "8739--8743",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "16",
}