Direct Catalytic Asymmetric Aldol Reaction of an α-Azido Amide

Karin Weidner, Zhongdong Sun, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

52 被引用数 (Scopus)

抄録

A direct aldol reaction of an α-azido 7-azaindolinylamide, promoted by a Cu-based cooperative catalyst, is documented. Aromatic aldehydes bearing an ortho substituent exhibited diastereodivergency depending on the nature of the chiral ligands used. Smooth reactions with ynals highlighted the broad substrate scope. A vicinal azido alcohol unit in the product allowed direct access to the corresponding aziridine and facile hydrolysis of the 7-azaindolinylamide moiety furnished enantioenriched β-hydroxy-α-azido carboxylic acid derivatives.

本文言語English
ページ(範囲)6236-6240
ページ数5
ジャーナルAngewandte Chemie - International Edition
54
21
DOI
出版ステータスPublished - 2015 5 18
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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