Direct Catalytic Asymmetric Aldol Reaction of Thioamide with an α-Vinyl Appendage

Jin Cui, Akimichi Ohtsuki, Takumi Watanabe, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

14 被引用数 (Scopus)

抄録

The direct catalytic asymmetric aldol reaction is an emerging catalytic methodology that provides atom-economical access to functionalized chiral building blocks. Thioamides are useful aldol donors due to their high-fidelity chemoselective enolization and divergent post-aldol transformations. Herein we describe the incorporation of an α-vinyl appendage on a thioamide, which expands the utility of aldol adducts for natural product synthesis. This vinylated thioamide was not accommodated under the previously identified catalyst settings, but the newly developed catalytic conditions furnished aldol products containing the pendant vinyl group.

本文言語English
ページ(範囲)2598-2601
ページ数4
ジャーナルChemistry - A European Journal
24
11
DOI
出版ステータスPublished - 2018 2月 21
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 有機化学

フィンガープリント

「Direct Catalytic Asymmetric Aldol Reaction of Thioamide with an α-Vinyl Appendage」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル