抄録
Direct catalytic asymmetric conjugate addition of thiolactams to α,β-unsaturated thioamides was efficiently promoted by a soft Lewis acid/hard Brønsted base cooperative catalyst in a highly stereocontrolled manner. Thioamide functionality was crucial to promote both the efficient enolization of thiolactam pronucleophiles and the subsequent stereoselective conjugate addition to α,β-unsaturated thioamides. Differential manipulation of the two thioamide functionalities of the product highlights the synthetic utility of the present catalytic system. (Chemical Equation Presented).
本文言語 | English |
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ページ(範囲) | 3362-3365 |
ページ数 | 4 |
ジャーナル | Organic Letters |
巻 | 17 |
号 | 13 |
DOI | |
出版ステータス | Published - 2015 7月 2 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学