Direct Catalytic Asymmetric Conjugate Addition of Saturated and Unsaturated Thioamides

Nilanjana Majumdar, Akira Saito, Liang Yin, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Direct catalytic asymmetric conjugate addition of thiolactams to α,β-unsaturated thioamides was efficiently promoted by a soft Lewis acid/hard Brønsted base cooperative catalyst in a highly stereocontrolled manner. Thioamide functionality was crucial to promote both the efficient enolization of thiolactam pronucleophiles and the subsequent stereoselective conjugate addition to α,β-unsaturated thioamides. Differential manipulation of the two thioamide functionalities of the product highlights the synthetic utility of the present catalytic system. (Chemical Equation Presented).

本文言語English
ページ(範囲)3362-3365
ページ数4
ジャーナルOrganic Letters
17
13
DOI
出版ステータスPublished - 2015 7 2
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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