Direct catalytic asymmetric intramolecular conjugate addition of thioamide to α,β-unsaturated esters

Yuta Suzuki, Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Proton transfer allows efficient access to optically active five- and six-membered ring systems bearing ester and thioamide functionalities in an anti fashion; these ring systems are amenable to differential functional group manipulation. Direct catalytic, asymmetric, intramolecular conjugate addition of thioamide to α,β-unsaturated esters is described. In situ generated Cu thioamide enolate, by catalytic deprotonation, underwent the conjugate addition/protonation, to achieve the complete transformation (see scheme).

本文言語English
ページ(範囲)11998-12001
ページ数4
ジャーナルChemistry - A European Journal
17
43
DOI
出版ステータスPublished - 2011 10 17
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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