@article{cb6f8a22cb794f879fc7522fb07e0b2e,
title = " Direct Catalytic Asymmetric Mannich-Type Reaction of an α-CF 3 Amide to Isatin Imines ",
abstract = " An α-CF 3 amide underwent direct asymmetric Mannich-type reaction to isatin imines in the presence of a chiral catalyst comprising a soft Lewis acid Cu(I), a chiral bisphosphine ligand, and Barton's base. The Mannich adduct was converted in one step into a unique tricycle bearing a trifluoromethylated chiral center and an α-tertiary amine moiety. ",
keywords = "asymmetric catalysis, copper catalysis, fluorine, heterocycle, Mannich reaction",
author = "Yu, {Jin Sheng} and Hidetoshi Noda and Naoya Kumagai and Masakatsu Shibasaki",
note = "Funding Information: This work was financially supported by the ACT-C program (JPM-JCR12YO) from JST and KAKENHI (17H03025, JP18K14878, and 18H04276 in Precisely Designed Catalysts with Customized Scaffold- ing) from JSPS and MEXT. J.-S.Y. was supported by a JSPS International Research Fellowship.() Publisher Copyright: {\textcopyright} Georg Thieme Verlag.",
year = "2019",
doi = "10.1055/s-0037-1611642",
language = "English",
volume = "30",
pages = "488--492",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
number = "4",
}