Direct catalytic asymmetric mannich-type reaction of thioamides

Yuta Suzuki; Ryo Yazaki; Naoya Kumagai; Masakatsu Shibasaki

doi:10.1002/anie.200901588

Direct catalytic asymmetric mannich-type reaction of thioamides

Yuta Suzuki, Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article › 査読

59 被引用数 (Scopus)

抄録

Taking the reins: The title transformation of thioamides and N-diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme). Divergent transformation of the thioamide functionality highlights the utility of this methodology.

本文言語	English
ページ（範囲）	5026-5029
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	48
号	27
DOI	https://doi.org/10.1002/anie.200901588
出版ステータス	Published - 2009 6月 22
外部発表	はい

ASJC Scopus subject areas

触媒
化学 (全般)

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10.1002/anie.200901588

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abstract = "Taking the reins: The title transformation of thioamides and N-diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Br{\o}nsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme). Divergent transformation of the thioamide functionality highlights the utility of this methodology.",

keywords = "Asymmetric catalysis, Copper, Mannich reactions, Proton transfer, Thioamides",

author = "Yuta Suzuki and Ryo Yazaki and Naoya Kumagai and Masakatsu Shibasaki",

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AU - Kumagai, Naoya

AU - Shibasaki, Masakatsu

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AB - Taking the reins: The title transformation of thioamides and N-diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme). Divergent transformation of the thioamide functionality highlights the utility of this methodology.

KW - Asymmetric catalysis

KW - Copper

KW - Mannich reactions

KW - Proton transfer

KW - Thioamides

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Direct catalytic asymmetric mannich-type reaction of thioamides

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