TY - JOUR
T1 - Direct impact of motor cortical stimulation on the blood oxygen-level dependent response in rats
AU - Xin, Zonghao
AU - Abe, Yoshifumi
AU - Liu, Shuang
AU - Tanaka, Kenji F.
AU - Hosomi, Koichi
AU - Saitoh, Youichi
AU - Sekino, Masaki
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Research Fellowships of the Japan Society for the Promotion of Science (JSPS Research Fellow) under grant number 18J00922 (Y.A.). We gratefully acknowledge the help from J. Gu and D. Kim for supporting the experiment and animal handling.
Publisher Copyright:
© 2020 Japanese Society for Magnetic Resonance in Medicine.
PY - 2021
Y1 - 2021
N2 - Purpose: Neuropathic pain is a complex and distressing chronic illness in modern medicine. Since 1990s, motor cortex stimulation (MCS) has emerged as a potential treatment for chronic neuropathic pain; however, the precise mechanisms underlying analgesia induced by MCS are not completely understood. The purpose of the present study was to investigate the blood oxygen-level dependent (BOLD) response in the brain during MCS. Methods: We inserted a bipolar tungsten electrode into the primary motor cortex (M1) of adult male Wistar rats. Functional magnetic resonance imaging (fMRI) scans were implemented simultaneously with the electrical stimulation of M1 and the BOLD signals taken from the fMRI were used as an index to reflect the response against MCS. Results: Our results demonstrated that the bilateral M1, ipsilateral caudate-putamen, and ipsilateral primary somatosensory cortex to the stimulation spot were activated after the onset of MCS. The BOLD signal time courses were analysed in these regions and similar temporal characteristics were found. Conclusion: By conducting direct cortical stimulation of the rodent brain to investigate its instant effect using fMRI, we identified encephalic regions directly involved in the instant motor cortical stimulation effects in healthy rat models. This result may be essential in establishing a foundation for further research on the underlying neuropathways associated with the MCS effects.
AB - Purpose: Neuropathic pain is a complex and distressing chronic illness in modern medicine. Since 1990s, motor cortex stimulation (MCS) has emerged as a potential treatment for chronic neuropathic pain; however, the precise mechanisms underlying analgesia induced by MCS are not completely understood. The purpose of the present study was to investigate the blood oxygen-level dependent (BOLD) response in the brain during MCS. Methods: We inserted a bipolar tungsten electrode into the primary motor cortex (M1) of adult male Wistar rats. Functional magnetic resonance imaging (fMRI) scans were implemented simultaneously with the electrical stimulation of M1 and the BOLD signals taken from the fMRI were used as an index to reflect the response against MCS. Results: Our results demonstrated that the bilateral M1, ipsilateral caudate-putamen, and ipsilateral primary somatosensory cortex to the stimulation spot were activated after the onset of MCS. The BOLD signal time courses were analysed in these regions and similar temporal characteristics were found. Conclusion: By conducting direct cortical stimulation of the rodent brain to investigate its instant effect using fMRI, we identified encephalic regions directly involved in the instant motor cortical stimulation effects in healthy rat models. This result may be essential in establishing a foundation for further research on the underlying neuropathways associated with the MCS effects.
KW - Caudate-putamen
KW - Functional magnetic resonance imaging
KW - Motor cortex stimulation
KW - Primary motor cortex
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U2 - 10.2463/mrms.mp.2019-0156
DO - 10.2463/mrms.mp.2019-0156
M3 - Article
C2 - 32307360
AN - SCOPUS:85102408810
VL - 20
SP - 83
EP - 90
JO - Magnetic Resonance in Medical Sciences
JF - Magnetic Resonance in Medical Sciences
SN - 1347-3182
IS - 1
ER -